Bedlington Terrier Melbourne 


Bedlington Terrier Melbourne

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Copper toxicosis, also known as copper storage disease and copper overload syndrome, is an autosomal recessive disease that is characterized by an accumulation of copper in ... Read more the liver. It is closely related to Wilson's disease in humans. Bedlington Terriers are more prone to copper toxicosis than most other dog breeds. West Highland White Terriers, Skye Terriers, and Doberman Pinschers are also prone to copper storage disease. Bedlington Terriers are the only breed of dog in which haemolysis has been reported, but there have been no reports of neurological involvement in any dog breed. Studies have shown that in Bedlingtons, the disease is caused by a defective metallothionein that causes cell lysosomes to become saturated with copper. This causes the cell to store copper in the nucleus. There are three varieties of the disease: the Asymptomatic Form occurs when copper accumulates but there are no clinical symptoms of the disorder; the Fulminating Form which is seen mostly in young dogs, causes death in two to three days, and is thought to be caused by stress; and the Chronic Form, which is characterized by an extended period of time in which liver disease slowly causes the death of the dog. Bedlingtons also have a tendency to accumulate iron in the liver, but not nearly to the extent that they accumulate copper.

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